Alexander L. Shaver*, Ph.D.
Primary Areas of Practice
Overview
Alexander Shaver ("Alex") supports the attorneys in the firm’s Life Sciences patent prosecution practice. He brings to his role a wealth of experience and training in life sciences technologies.
Prior to joining Rothwell Figg, Alex was a Senior Fellow at Johns Hopkins Technology Ventures, where he created academic, market, and patent landscape reports for Johns Hopkins inventions. Promoted to a management position within 10 months, Alex coordinated a five-person team evaluating over 50 medical devices, therapeutics, and treatment methods.
Alex received Bachelor of Science degrees in Chemistry and Microbiology at the University of Alabama. While there, he worked as an undergraduate research assistant and tutor, synthesizing novel nucleotide phosphoramidites using organic chemistry techniques, and teaching general, analytic, and organic chemistry. He was also a research assistant in the Washington University in Saint Louis Center for Cardiovascular Research, studying the lysosomal stress pathway to the model organism C. elegans.
As a Ph.D. student in Pharmacology and Molecular Sciences, Alex wrote his thesis on “Extending the Operational Lifetime of Electrochemical Aptamer-based Sensors”. He published five first-author manuscripts and co-authored two more about biosensors for small molecule therapeutics. Throughout his time in the lab, Alex developed a wealth of knowledge in electrochemistry, biosensor engineering, DNA biophysics, and small molecule therapeutics.
In his spare time, Alex is a collector and avid player of board games (particularly Monopoly) and enjoys Marvel Comics, reading novels, and baking cookies.
Newsroom
Publications
Critical review—Approaches for the electrochemical interrogation of DNA-based sensors: A critical review
MA Pellitero, A Shaver, N Arroyo-Currás
Journal of The Electrochemical Society 167 (3), 037529
Alkanethiol monolayer end groups affect the long-term operational stability and signaling of electrochemical, aptamer-based sensors in biological fluids
A Shaver, SD Curtis, N Arroyo-Curras
ACS applied materials & interfaces 12 (9), 11214-11223
Microneedle aptamer-based sensors for continuous, real-time therapeutic drug monitoring
Y Wu, F Tehrani, H Teymourian, J Mack, A Shaver, M Reynoso, J Kavner, ...
Analytical Chemistry 94 (23), 8335-8345
The challenge of long-term stability for nucleic acid-based electrochemical sensors
A Shaver, N Arroyo-Currás
Current opinion in electrochemistry 32, 100902
Nuclease hydrolysis does not drive the rapid signaling decay of DNA aptamer-based electrochemical sensors in biological fluids
A Shaver, N Kundu, BE Young, PA Vieira, JT Sczepanski, ...
Langmuir 37 (17), 5213-5221
Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival
JT Murphy, H Liu, X Ma, A Shaver, BM Egan, C Oh, A Boyko, T Mazer, ...
PLoS biology 17 (5), e3000245
Optimization of vancomycin aptamer sequence length increases the sensitivity of electrochemical, aptamer-based sensors in vivo
A Shaver, JD Mahlum, K Scida, ML Johnston, M Aller Pellitero, Y Wu, ...
ACS sensors 7 (12), 3895-3905
Expanding the Monolayer Scope for Nucleic Acid-Based Electrochemical Sensors Beyond Thiols on Gold: Alkylphosphonic Acids on ITO
A Shaver, N Arroyo-Currás
ECS Sensors Plus 2 (1), 010601
Correction to “Nuclease Hydrolysis Does Not Drive the Rapid Signaling Decay of DNA Aptamer-Based Electrochemical Sensors in Biological Fluids”
A Shaver, N Kundu, BE Young, PA Vieira, JT Sczepanski, ...
Langmuir 38 (4), 1651-1651
Community & Professional
Phi Beta Kappa
American Chemical Society
Gamma Sigma Epsilon
Beta Beta Beta
Practices
Education
Ph.D., Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine
B.S., Chemistry and B.S, Microbiology, The University of Alabama (summa cum laude)